Medical Research - MOPH Qatar Diabetes Newsletter - 28th Feb 2018

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Working Nights May Raise Diabetes Risk

Night-shift work is linked to an increased risk for Type 2 diabetes, a new study has found. British and American researchers used a large health database to compare diabetes prevalence in 47,286 night-shift workers with that of 224,928 day workers. The database included information on age, sex, race, family history of diabetes, alcohol use, sleep duration, body mass index and other health and behavioral characteristics, as well as diagnoses of diabetes. The more often people worked nights, the more likely they were to have diabetes. Compared with day workers, people who occasionally worked night shifts were 15 percent more likely to have diabetes; those who rotated shifts with some night work were 18 percent more likely; and those who worked irregular shifts with frequent night shifts were 44 percent more likely to have Type 2 diabetes.
21st Feb 2018 - New York Times

Shift work increases type 2 diabetes risk regardless of genetics, study says

13th Feb 2018 - Diabetes.co.uk

Study Ties Shift Work, Genetic Risks With Type 2 Diabetes

20th Feb 2018 - Information About Diabetes.com

Rotating night shifts a path to diabetes, study suggests

20th Feb 2018 - UPI.com

Rotating Night Shifts a Path to Diabetes, Study Suggests

20th Feb 2018 - U.S. News & World Report

Rotating night shifts may be a path to diabetes, study suggests

20th Feb 2018 - Chicago Tribune

Landmark Pune study on diabetes begins testing the third generation

Research by Chittaranjan Yajnik, head of the Diabetes Research Centre at KEM hospital, showed that mothers with low Vitamin B12 and excess folate levels (level of folic acid) predispose their babies to adiposity and insulin resistance that are key risk factors for diabetes. That landmark research helped in explaining why diabetes was so widely prevalent in India, even among malnourished populations, when, globally, the disease was very commonly associated with obesity. The participants have been followed now over three generations and practical intervention-based outcomes based on the findings are now being followed up with the latest generation
21st Feb 2018 - The Indian Express

Landmark Pune study on diabetes begins testing the third generation

21st Feb 2018 - Indian Express

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #114: Diabetes and Sleep Apnea Part 4

OSA and dysglycemia have similar risk factors (namely obesity) and hence it is not surprising that these conditions co-exist. However, not all obese patients have both conditions and many patients have one and not the other. Hence, understanding this association and the mechanisms that underpin this relationship is important to understand the pathogenesis of OSA and T2DM.
27th Feb 2018 - Diabetes In Control

Study suggests new strategy against vascular disease in diabetes

Cardiovascular problems from atherosclerosis - plaque-like lesions forming in artery walls - are the major cause of death in people with type 2 diabetes and metabolic syndrome. People with metabolic syndrome exceed the normal range for several clinical measurements: blood pressure, blood sugar levels, harmful lipids, body mass index, and belly fat. The researchers studied mice with metabolic syndrome. The mice were obese and had impaired glucose tolerance, a sign of pre-diabetes. In the study, an insulin-mimicking synthetic peptide called S597 was shown to both reduce blood sugar levels and slow the progression of atherosclerotic lesions. Insulin, even when it controls diabetes, does not prevent atherosclerosis.
26th Feb 2018 - Medical Xpress

Earlier diabetes diagnosis linked to heart disease, stroke

Being diagnosed 10 years earlier amounted to a 20 to 30 percent higher risk of all-cause mortality, and a 60 percent higher risk of dying of heart disease. The results were just as strong for both men and women. "Evidence is accumulating," the authors write, "to suggest that earlier onset of type 2 diabetes is associated with an increased risk of complications and comorbidities compared with later onset, and that the development and progression of complications might be more aggressive in those with earlier onset." "As such," the authors continue, "increased clinical attention is imperative for individuals with earlier-onset type 2 diabetes."
26th Feb 2018 - Medical News Today

A new study suggests younger type-2 diabetes is bad for the heart

A new study suggests younger-onset type 2 diabetes increases the risk of death from heart attack and stroke. The earlier a person is diagnosed with type 2 diabetes, the higher their risk of dying from heart attack and stroke, an Australian study has found. The concerning finding has prompted calls for more "aggressive" prevention and intervention to prevent the delay the onset of T2D in young people.
23rd Feb 2018 - Health Times.com.au

Workers with diabetes retire two years later according to Finnish study

A total of 12,726 people, born between 1934 and 1944 and part of the Helsinki Birth Cohort Study, were monitored to see how health impacted their working life. Finnish researchers reviewed the records between 1971 and 2011 to see how many people had developed diabetes and who had retired. Within women, 49% of those with diabetes transitioned into old-age pension, rather than retiring early. This was a higher figure than the 40% of those without diabetes. Likewise, in men, 41% with diabetes transitioned into old-age pension compared with 33% of those without diabetes. In terms of the average retirement age, average retirement age was over two years later in those with diabetes. Within women the average retirement age was 61.4 years-old or those with diabetes and 59.5 years-old for those without the condition. In men, average retirement was at 60.1 years-old in those with diabetes and 57.6 in those without.
20th Feb 2018 - Diabetes.co.uk

Diabetes study in Whyalla

“In Australia, about 30% of the adult Indigenous population has diabetes, and the numbers continue to rise. Diabetes is increasing in Aboriginal children, teenagers and young adults, with rising rates of diabetes in pregnancy. The reason for this is not fully understood. Whilst diet, exercise levels and weight gain are known to contribute to diabetes, they do not fully explain the high rate of diabetes and why some people get very sick. The Aboriginal Diabetes Study aims to: Better understand the problem of diabetes and its complications. Better predict the development of diabetes complications. Improve diabetes care to Aboriginal people and prevent complications. All Aboriginal and Torres Strait Islander people aged 15 years and over – with and without diabetes – are invited to participate.
20th Feb 2018 - Whyalla News

Study people with heavy thighs unlikely to become diabetic

The findings published in a recent edition of the Indian Journal of Endocrinology and Metabolism suggests that thigh circumference can predict diabetes. "Big tummy with thin thighs is equal to high risk of diabetes and slim tummy with big thighs is equal to low risk of diabetes," the study said.
20th Feb 2018 - Indian Express

Study reveals New Monogenic Form of diabetes in India

The study was carried out was based on a comprehensive genomic analysis of 289 individuals from India which included 152 clinically diagnosed MODY cases and 137 normal glucose tolerance subjects (NGT). None of the NGT subjects showed any genetic variants associated with MODY. Among the 152 clinically diagnosed MODY subjects, MODY 3 was found to be the commonest MODY which is in keeping with studies in Europe and UK. However, surprisingly, the second commonest MODY detected in India was MODY 12, (ABCC8 MODY). Moreover, 13 of the 14 known forms of MODY were detected in Indians. However, of great interest was the discovery of a novel MODY gene, the NKX6-1 gene which was found to be associated with MODY. Functional assessment of the NKX6-1 variant showed that they were functionally impaired, confirming that they were indeed the cause of MODY’
20th Feb 2018 - Economic Times

MedGenome, MDRF and Genentech study indicates a new Monogenic form of Diabetes in India

21st Feb 2018 - Pharmabiz

Lupin plant could help treat heart disease, diabetes - study

A team of researchers from Spain and Australia have shown that seed-proteins, or conglutins, in narrow-leafed lupins can provide alternative therapies for diseases such as cardiovascular disease, cancer, type 2 diabetes and hypertension. The study, recently published in the Journal of Functional Foods evaluated the effects of conglutins in 14 healthy and 14 diabetic patients. It found the proteins could help reverse harmful effects of inflammatory diseases.
20th Feb 2018 - Radio New Zealand

Study Shows Long-Term Effects Of Diabetes And Prediabetes On The Brain

One of the largest studies on the connection between blood sugar and brain function has found that people with prediabetes and diabetes experience worse long-term cognitive decline than people with normal blood sugar levels. The results underscore just how dangerous impaired blood sugar is for overall health, from heart to brain – but the study also suggests that there’s a possible good news side to this story.
28th Jan 2018 - Forbes