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"Seqirus Media Monitoring" 13th Sep 2017

News Highlights
Seqirus’ adjuvanted quadrivalent flu vaccine shows better protection for young children Seqirus already has the first and only FDA-approved cell-based flu vaccine, Flucelvax, for people four years and older. Now, aiming for a younger population, the CSL subsidiary has returned with phase 3 data showing an adjuvanted quadrivalent flu shot could be a better choice than non-adjuvanted option
Move to adjuvanted flu vaccine could help over-65s Over 1,700 flu deaths a year in the UK could be avoided by switching to a new flu vaccine, according to new health economic modelling presented at the ESWI meeting; Fluad uses an adjuvant which helps the body’s immune system develop a strong response to flu, particularly in people 65 years and over
Flu vaccine for the over 65s: adjuvanted vaccine more efficient against influenza New results presented at the European Scientific Working Group on Influenza (ESWI) Congress in Riga indicate that the adjuvanted vaccine produces a better immune response against influenza in the over 65 population than the non-adjuvanted vaccine
New Phase III Study Shows Significantly Greater Efficacy in Children 6-24 Months Who Receive Adjuvanted Influenza Vaccine (aQIV) Annual flu-related hospitalizations among U.S. children under 5 have ranged from 7,000 to 26,000 since 2010, with annual reported deaths from 37 to 171 during regular influenza seasons in the same time span. One potential solution to reducing these hospitalizations and deaths is with a more effective vaccine for children
Changes Include Newly Licensed Products, Expanded Age Indication Two vaccines are newly licensed for use during the 2017-2018 season. They are Seqirus' quadrivalent inactivated influenza vaccine (IIV4) Afluria Quadrivalent -- licensed for use in patients ages 5 years and older -- and Protein Sciences' new IIV4 formulation Flublok Quadrivalent -- approved for use in adults 18 and older.
Sanofi names a new president in France Guillaume Leroy will be the new head of Sanofi France from October 1st, replacing Philippe Luscan ; he will coordinate all of Sanofi’s activities in France and represent the company in dealings with French authorities and professional bodies
Resolve health initiative aims to save 100m lives worldwide A new initiative to save 100 million lives globally through simple interventions such as cutting down on salt and banning trans fats, as well as getting countries prepared for epidemics from flu to SARS, is being launched with $225m of philanthropic funding, by Dr Tom Frieden, former director of the CDC in the United States
UK first EU market for Sanofi Pasteur quadrivalent flu vaccine Sanofi Pasteur announced that, for the first time, it is making available its quadrivalent influenza vaccine in the UK, making it the first European country to market Sanofi Pasteur’s quadrivalent influenza vaccine
A new flu vaccine is now available in the Czech Republic The VaxigripTetra vaccine was approved in the European Union in 2016 and is now also approved for use in the Czech Republic. The 2017-2018 flu season in the northern hemisphere will be the first influenza season when VaxigripTetra will be available for populations aged 3 years and over in 24 countries
Researchers elucidate immune response to flu vaccine Researchers have discovered gene signatures associated with the immune response to the influenza vaccination; they found nine genes and three gene clusters by studying antibody response in over 500 people. Findings from the study could be used to develop strategies to predict and improve the immune system’s response to vaccines
Compulsory vaccination bill to be tabled in joint session of parliament In Pakistan, the Senate passed a motion for ‘The Islamabad Compulsory Vaccination and Protection of Health Workers Bill, 2015’ to be tabled in a joint session of the parliament for approval; Senator Farooq said the bill will play a vital role in increasing children‘s immunity
NHS boss puts service on high alert in case of heavy winter flu burden Britain could face a significant increase in flu cases this winter, which would make it hard for hospitals, GP surgeries and care homes to cope, the chief executive of NHS England said
Seqirus
Seqirus’ adjuvanted quadrivalent flu vaccine shows better protection for young children
Seqirus already has the first and only FDA-approved cell-based flu vaccine, Flucelvax, for people four years and older. Now, aiming for a younger population, the CSL subsidiary has returned with phase 3 data showing an adjuvanted quadrivalent flu shot could be a better choice than non-adjuvanted option
Flu vaccine for the over 65s: adjuvanted vaccine more efficient against influenza
New results presented at the European Scientific Working Group on Influenza (ESWI) Congress in Riga indicate that the adjuvanted vaccine produces a better immune response against influenza in the over 65 population than the non-adjuvanted vaccine
Move to adjuvanted flu vaccine could help over-65s
Over 1,700 flu deaths a year in the UK could be avoided by switching to a new flu vaccine, according to new health economic modelling presented at the ESWI meeting; Fluad uses an adjuvant which helps the body’s immune system develop a strong response to flu, particularly in people 65 years and over
Seqirus’ adjuvanted quadrivalent flu vaccine shows better protection for young children
Seqirus already has the first and only FDA-approved cell-based flu vaccine, Flucelvax, for people four years and older. Now, aiming for a younger population, the CSL subsidiary has returned with phase 3 data showing an adjuvanted quadrivalent flu shot could be a better choice than non-adjuvanted options.
New Phase III Study Shows Significantly Greater Efficacy in Children 6-24 Months Who Receive Adjuvanted Influenza Vaccine (aQIV)
Annual flu-related hospitalizations among U.S. children under 5 have ranged from 7,000 to 26,000 since 2010, with annual reported deaths from 37 to 171 during regular influenza seasons in the same time span. One potential solution to reducing these hospitalizations and deaths is with a more effective vaccine for children
Changes Include Newly Licensed Products, Expanded Age Indication
Two vaccines are newly licensed for use during the 2017-2018 season. They are Seqirus' quadrivalent inactivated influenza vaccine (IIV4) Afluria Quadrivalent -- licensed for use in patients ages 5 years and older -- and Protein Sciences' new IIV4 formulation Flublok Quadrivalent -- approved for use in adults 18 and older.
CDC: Influenza Vaccine Slightly Modified for New Season
Afluria (IIV3; Seqirus, Parkville, Victoria, Australia) is now recommended for persons aged 5 years and older, in line with FDA-approved labeling. Afluria Quadrivalent (IIV4; Seqirus, Parkville, Victoria, Australia) was licensed by the FDA in August last year for adults aged 18 and older.
Pandemic Influenza News
Nigeria’s southwest state activates bird flu control measures
Nigeria’s southwest Ogun State activated bird flu control measures at a breeder poultry farm, located in Orile-Ilugun area of the state, to prevent the spread of Avian Influenza H5N8, which was discovered on the farm
H7N9 Avian Flu Continues to Spread, Worsen in China
The latest epidemic of Asian lineage avian influenza A (Asian H7N9) in China infected almost as many patients as the four previous outbreaks combined and gave rise to a variant less susceptible to available treatments and vaccines, researchers report
Industry News
Resolve health initiative aims to save 100m lives worldwide
A new initiative to save 100 million lives globally through simple interventions such as cutting down on salt and banning trans fats, as well as getting countries prepared for epidemics from flu to SARS, is being launched with $225m of philanthropic funding, by Dr Tom Frieden, former director of the CDC in the United States
Sanofi names a new president in France
Guillaume Leroy will be the new head of Sanofi France from October 1st, replacing Philippe Luscan ; he will coordinate all of Sanofi’s activities in France and represent the company in dealings with French authorities and professional bodies
A new flu vaccine is now available in the Czech Republic
The VaxigripTetra vaccine was approved in the European Union in 2016 and is now also approved for use in the Czech Republic. The 2017-2018 flu season in the northern hemisphere will be the first influenza season when VaxigripTetra will be available for populations aged 3 years and over in 24 countries
UK first EU market for Sanofi Pasteur quadrivalent flu vaccine
Sanofi Pasteur announced that, for the first time, it is making available its quadrivalent influenza vaccine in the UK, making it the first European country to market Sanofi Pasteur’s quadrivalent influenza vaccine
BioCryst Pharmaceuticals Commences Public Offering of Common Stock
BioCryst Pharmaceuticals announced that it is offering to sell $80 million of its common stock in an underwritten public offering
Academic studies
Low uptake of flu vaccination among healthcare workers influenced by social attitudes
The low uptake of flu vaccination among medical students and doctors is influenced by social attitudes say researchers. Despite a recommendation from the Chief Medical Officer for England that all healthcare workers are vaccinated annually, only 55% are protected against the spread of influenza, this could contribute to staff sickness and mortality among elderly patients
Researchers elucidate immune response to flu vaccine
Researchers have discovered gene signatures associated with the immune response to the influenza vaccination; they found nine genes and three gene clusters by studying antibody response in over 500 people. Findings from the study could be used to develop strategies to predict and improve the immune system’s response to vaccines
Tobacco plant may 'save lives' in new flu vaccine trial, Austin researchers say
TEKTON Research in Austin is testing a flu vaccine that could be made faster than the current vaccine, using tobacco
Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice
Development of novel adjuvants is needed to enhance immunogenicity to provide better protection from seasonal influenza virus infection and improve pandemic preparedness. A study shows that several dose combinations of synthetic TLR4 and TLR7 ligands are potent adjuvants for recombinant influenza virus hemagglutinin antigen induction of humoral and cellular immunity against viral challenges
Pediatric influenza news
US paediatricians recommend flu vaccinations for children over 6 months
Children over six months of age should be vaccinated against influenza, according to the American Academy of Pediatrics (AAP), which could significantly reduce the risk of serious illnesses and deaths
Maternity services across Somerset give free flu vaccines
Midwives in maternity services across Somerset are offering the free flu vaccine when they see pregnant women at ante-natal clinics, scans and other appointments
School flu vaccines for four-year-olds will 'considerably' decrease GP workload
Removing four-year-olds from this year's GP influenza vaccination programme and administering vaccines in schools will boost uptake and reduce practice workload dealing with influenza-like illness, UK GPs say
Performance of inhaled flu vaccine confounds experts
Why the live-attenuated influenza vaccine FluMist performed poorly in America during the 2015-16 flu season but well in Canada, Finland, and the United Kingdom continues to stump flu experts
PATH points to power of $120M core boost with new vaccine initiative
The global health organization PATH announced the launch of a new initiative on maternal immunisation; the Advancing Maternal Immunization program will provide pregnant women with vaccines to protect their babies from infectious diseases
Over 65’s influenza news
There are more than 30,000 people vaccinated against flu but some elderly in Cali, Colombia, are very hard to reach
In Cali, Colombia, not enough older people get immunised against the flu and become seriously ill as a result, so the health secretary has made available 30,000 free flu vaccines for this vulnerable population until September 15th
Free Webinar Aims to Boost Flu Vaccinations in Older Adults
A free AAFP webinar (register.gotowebinar.com) scheduled for Sept. 26 from 11 a.m. to noon CDT seeks to help family physicians increase their influenza vaccination rates, especially among patients ages 65 and older
General Influenza News
Compulsory vaccination bill to be tabled in joint session of parliament
In Pakistan, the Senate passed a motion for ‘The Islamabad Compulsory Vaccination and Protection of Health Workers Bill, 2015’ to be tabled in a joint session of the parliament for approval; Senator Farooq said the bill will play a vital role in increasing children‘s immunity
NHS boss puts service on high alert in case of heavy winter flu burden
Britain could face a significant increase in flu cases this winter, which would make it hard for hospitals, GP surgeries and care homes to cope, the chief executive of NHS England said
Review Updated Flu Prevention Guidance for 2017-2018
The CDC has released its yearly flu vaccination recommendations in Morbidity and Mortality Weekly Report. The updated recommendations were discussed and voted on during meetings of the agency's Advisory Committee on Immunization Practices (ACIP) held in October 2016, as well as those in February and June 2017
Hospitals, doctors fight bill that would end flu vaccine requirements
A fight over flu vaccination requirements is pitting Ohio’s medical and business communities against conservative lawmakers and those who say they are “committed to protecting control over our own bodies”
New Bill Would Make Employer-Required Flu Shots Illegal
In the U.S., some companies, especially those in the healthcare fields, require their employees to get flu shots each year. A newly released bill would make that requirement, for anyone, illegal
Pharmacists’ association lobbies for universal coverage
The Pharmacists’ Association of Newfoundland and Labrador has been pitching for free flu shots for years, not only for personal protection, but for vulnerable individuals who come into contact with others each day and who can become ill from influenza. That would mean residents of this province could obtain these shots from pharmacists as well as doctors
Burden of disease
Flu-related death toll in Tasmania rises to 21 as treatment stocks run low
Flu has contributed to more than half a dozen deaths in nursing homes in the past week in Tasmania as stocks of Tamiflu treatment run low, the public health director has said. Dr Mark Veitch said the flu season death toll had risen to 21 after a significant number of fresh outbreaks in the past week
Swine Flu Death Toll: 400 In Ahmedabad, 525 In Maharashtra; Here's How You Stay Safe
An official statement from the state government in Ahmedabad said that the death toll due to swine flu has reached 400 from January to September 11
Flu virus has residents in its grips
Huge numbers of Zululanders are seeking medical attention for severe coughs and body aches in what doctors are calling a recurring and aggressive strain of the influenza virus
Zimbabwe: Influenza Cases On the Increase
The Ministry of Health and Child Care in Zimbabwe is encouraging people to wear warm clothes, amid indications that cases of influenza are on the rise, with 7,483 suspected cases recorded in a week countrywide
Alarming 5-fold rise in swine flu deaths
There has been an alarming 16-fold rise in the number of swine flu cases and five-fold increase in deaths due to the H1N1 virus infection in India this year. According to the data available from the Union Health Ministry, a total of 29,076 cases have been registered so far in nine months in 2017 across the country against just 1,786 cases in 2016