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"Seqirus Media Monitoring" 25th Sep 2017

News Highlights
Routine use of new type of flu vaccine in older people 'could prevent 1,700 deaths' If older people were switched from a conventional non-adjuvanted vaccine currently used in the UK immunisation programme to an adjuvanted trivalent influenza vaccine (aTIV), 195,600 cases of influenza could be prevented, according to estimations by researchers; Seqirus announced last month that it could supply 10 million doses of Fluad in the UK for the 2018-19 flu season
The flu will kill more people in Australia Australia’s Health Ministry is considering adopting a more powerful form of the flu vaccine to cope with the epidemic. Health authorities have begun negotiations with Seqirus to market the FLUAD vaccine, which will increase the effectiveness of the influenza vaccine
How can we get more people to vaccinate against flu? Some parents have concerns about the safety of the flu vaccine; Australians were spooked by a 2010 incident when there was a temporary suspension of flu vaccine for children under five after reports of an increase in the rate of convulsions in children. The one vaccine found to be the cause (BioCSL/Seqiris Fluvax) is no longer approved for use in children younger than five
VaccinatioNCelebration Offers NC-Made Flu Shots at NCBiotech Oct. 17 The North Carolina Biotechnology Center is hosting the second annual VaccinatioNCelebration flu shot clinic all day Tuesday, Oct. 17, 2017, to highlight North Carolinians’ production of the newest generation of flu vaccine. The vaccine, Flucelvax Quadrivalent, is made at the $1 billion Seqirus biomanufacturing facility in Holly Springs from a cell culture process rather than the traditional growing of the key component in chicken eggs.
Pharma in talks to bring super flu vaccine to Australia Australian Health Minister Greg Hunt asked chief medical officer Brendan Murphy to look at ways to boost the strength or effectiveness of the influenza vaccine next year. “Sanofi Pasteur has begun very high-level, preliminary discussions with Australia’s chief medical officer regarding our high-dose influenza vaccine. We are committed to assist both the Health Department and the Australian community to reduce the impact of influenza now and in the future” said a Sanofi spokesperson
BioCryst scores FDA approval on flu treatment for children On the heels of an $80 million public offering, BioCryst has landed U.S. Food and Drug Administration approval for Rapivab, its injectable flu treatment in pediatric patients
SK Chemicals awarded ‘2017 New Drug Grand Prize’ SK Chemicals has received the “2017 New Drug Grand Prize” from the Korean Ministry of Food and Drug Safety. “This is recognition of SK Chemicals’ innovative R&D achievements in the biotechnology field such as vaccines and blood products,” the company said. SK Chemicals has commercialized Skycellflu, the world's first quadrivalent cell culture flu vaccine
Atriva reaches a development milestone and receives an additional tranche of running seed financing to develop its influenza therapeutic to clinical stage The next generation of Antiviral Therapies: Co-Led by Stichting Participatie Atriva and High-Tech Gründerfonds (HTGF), Atriva Therapeutics GmbH has received a second tranche of its running seed financing in total of € 3 Mn from Dutch, German and Canadian investors, after lead compound ATR-002 (Atriva’s antiviral MEK-Inhibitor against Influenza) has passed an important preclinical milestone paving the way to clinical development stage.
T1D Risk Increased Following Influenza A H1N1 Diagnosis in Children The 2009 pandemic influenza A H1N1 outbreak has been linked to an increased risk for new-onset type 1 diabetes in children under the age of 15, according to a study presented at the 53rd European Association for the Study of Diabetes Annual Meeting
Seqirus mentions
How can we get more people to vaccinate against flu?
Some parents have concerns about the safety of the flu vaccine; Australians were spooked by a 2010 incident when there was a temporary suspension of flu vaccine for children under five after reports of an increase in the rate of convulsions in children. The one vaccine found to be the cause (BioCSL/Seqiris Fluvax) is no longer approved for use in children younger than five
The flu will kill more people in Australia
Australia’s Health Ministry is considering adopting a more powerful form of the flu vaccine to cope with the epidemic. Health authorities have begun negotiations with Seqirus to market the FLUAD vaccine, which will increase the effectiveness of the influenza vaccine
Routine use of new type of flu vaccine in older people 'could prevent 1,700 deaths'
If older people were switched from a conventional non-adjuvanted vaccine currently used in the UK immunisation programme to an adjuvanted trivalent influenza vaccine (aTIV), 195,600 cases of influenza could be prevented, according to estimations by researchers; Seqirus announced last month that it could supply 10 million doses of Fluad in the UK for the 2018-19 flu season
Flu experts: Hoping for milder season, more effective vaccine
The CDC said some flu shots will protect against three flu viruses, while others protect against four flu viruses. There are two new flu vaccines: an inactivated version known as Afluria and Flublok. The CDC also has approved for the first time a cell-based candidate vaccine virus for flu vaccine production in the Northern Hemisphere
VaccinatioNCelebration Offers NC-Made Flu Shots at NCBiotech Oct. 17
The North Carolina Biotechnology Center is hosting the second annual VaccinatioNCelebration flu shot clinic all day Tuesday, Oct. 17, 2017, to highlight North Carolinians’ production of the newest generation of flu vaccine. The vaccine, Flucelvax Quadrivalent, is made at the $1 billion Seqirus biomanufacturing facility in Holly Springs from a cell culture process rather than the traditional growing of the key component in chicken eggs.
Pandemic Influenza News
Uganda, Zimbabwe infected by Highly Pathogenic Avian Influenza
Uganda and Zimbabwe have been added to the list of countries/regions affected by Highly Pathogenic Avian Influenza (HPAI)
Poultry keepers urged to take precautions to reduce bird flu risk
In light of the ongoing risk of avian flu, the four UK farming unions have been working together with government and the UK Poultry Health and Welfare Group to highlight the importance of maintaining high levels of on-farm biosecurity
Industry News
BioCryst scores FDA approval on flu treatment for children
On the heels of an $80 million public offering, BioCryst has landed U.S. Food and Drug Administration approval for Rapivab, its injectable flu treatment in pediatric patients
SK Chemicals awarded ‘2017 New Drug Grand Prize’
SK Chemicals has received the “2017 New Drug Grand Prize” from the Korean Ministry of Food and Drug Safety. “This is recognition of SK Chemicals’ innovative R&D achievements in the biotechnology field such as vaccines and blood products,” the company said. SK Chemicals has commercialized Skycellflu, the world's first quadrivalent cell culture flu vaccine
Atriva reaches a development milestone and receives an additional tranche of running seed financing to develop its influenza therapeutic to clinical stage
The next generation of Antiviral Therapies: Co-Led by Stichting Participatie Atriva and High-Tech Gründerfonds (HTGF), Atriva Therapeutics GmbH has received a second tranche of its running seed financing in total of € 3 Mn from Dutch, German and Canadian investors, after lead compound ATR-002 (Atriva’s antiviral MEK-Inhibitor against Influenza) has passed an important preclinical milestone paving the way to clinical development stage.
Vaccines prevent 3m deaths each year
After the 27th National Vaccination Symposium, GlaxoSmithKline Medical Advisor Prof. Dr. Anıl Dutta said that vaccination prevented many diseases every year and that a significant number of diseases were eliminated in many countries thanks to regular vaccination
Doctors, experts say no to FluMist for upcoming flu season
Flu season is quickly approaching which means parents are prepping for some unhappy kids as, once again, the FluMist is being tossed aside in favor of the flu shot. Last year, the American Academy of Pediatrics had already stopped recommending the nasal spray saying it was barely effective at preventing the virus
Why Novavax, Inc. Could Be a Gold Mine for Growth Investors
In August, Novavax announced that its flu vaccine produced superior hemagglutinin antigen inhibition antibody responses in ferrets compared to Sanofi's Fluzone and Fluzone HD. The preclinical results were so impressive that Novavax is rushing to advance the vaccine, which it now calls NanoFlu
Pharma in talks to bring super flu vaccine to Australia
Australian Health Minister Greg Hunt asked chief medical officer Brendan Murphy to look at ways to boost the strength or effectiveness of the influenza vaccine next year. “Sanofi Pasteur has begun very high-level, preliminary discussions with Australia’s chief medical officer regarding our high-dose influenza vaccine. We are committed to assist both the Health Department and the Australian community to reduce the impact of influenza now and in the future” said a Sanofi spokesperson
Here's A Play In BioCryst Pharmaceuticals That Markets Just Missed
For a company that just picked up a major FDA approval, BioCryst is trading remarkably flat. Premarket on Thursday, September 21, the company announced that the FDA has approved its RAPIVAB asset for pediatric use
Irish Medicines regulator faces legal suit over flu vaccine
The Irish medicines regulator is to be sued for its alleged failure to act upon safety concerns that were conveyed to it about the Pandemrix flu vaccine.
Academic studies
Experts: Pregnant women should get a flu shot, despite miscarriage study
A new government-funded study appears to show a link between flu shots in pregnant women and miscarriage, but experts warn families not to jump to conclusions
Vet researcher gets $700K to study swine diseases, influenza B virus
A Kansas State University veterinary researcher is taking aim at swine diseases with the help of two major grants. The NIH grant will be used to investigate the connections between respiratory swine disease and influenza B virus
Trial shows safety and tolerability of antisense oligomer for treatment of influenza A
A phase 1 clinical trial published in the British Journal of Clinical Pharmacology found that radavirsen -- an antisense oligomer that inhibits the production of certain influenza proteins -- is safe and well-tolerated in healthy individuals. Additional studies on radavirsen's potential as a treatment for influenza are warranted
Pediatric influenza news
Thousands of clinically at-risk Birmingham children don’t get flu vaccines
Nearly half of parents of children in the West Midlands at risk of serious illness or death from the flu are failing to get them vaccinated against the virus. Figures from Public Health England reveal 2,389 two-to-four year olds in the region considered at particular risk from flu due to existing health conditions went unvaccinated in 2016-17
The Pregnancy Vaccine Scare That Should Have Never Been
Paul A. Offit, professor of pediatrics and director of the Vaccine Education Center at the Children’s Hospital of Philadelphia, explains why the study saying that the influenza vaccine given in the first trimester of pregnancy might have caused miscarriages should not have been published
What Are The Side Effects Of The Flu Shot In Infants? Don't Let These Deter You
Doctors give the flu vaccine to patients as young as 6 months old, as catching the flu at this age can be devastating. The side effects of the vaccine are not serious, and the benefits far outweigh the risks
T1D Risk Increased Following Influenza A H1N1 Diagnosis in Children
The 2009 pandemic influenza A H1N1 outbreak has been linked to an increased risk for new-onset type 1 diabetes in children under the age of 15, according to a study presented at the 53rd European Association for the Study of Diabetes Annual Meeting
LAIV ineffective for children during 2015-2016 season
Although vaccination against influenza lessened the chances of illness, the live-attenuated vaccine demonstrated inefficacy and the inactivated vaccine demonstrated significant effectiveness in children for the 2015-2016 season, according to a study published in The New England Journal of Medicine
Libs promise free flu jabs for kids as nation reels from horror season
The Coalition in Victoria has promised to fund free flu vaccines for children aged between six months and five years old if it wins the 2018 state election. Making the flu shot free would send parents "a clear message that it is safe and responsible and important that children are vaccinated," the Liberals' health spokeswoman, Mary Wooldridge said
Take flu vaccine before winter starts in UAE, advise doctors
Parents must brace themselves and keep an eye out on their young ones, because flu season has arrived in the UAE, warn doctors. Dr Rashmi Mathia, internal medicine specialist, Universal Hospital, recommends taking the flu shot each year
Are you doing everything you can for your's child's health? Parents failing to protect children from flu
Around two in five parents of children in Gloucestershire at risk of serious illness or death from the flu are failing to get them vaccinated against the virus. Figures from Public Health England reveal 266 two-to-four year olds in the county considered at particular risk from flu due to existing health conditions went unvaccinated in 2016-17
Flu program to cover parents of infants
In Taiwan, government-funded influenza vaccines will be available starting next week, the Centers for Disease Control said, adding that parents with infants younger than six months old and people who work at preschools or nurseries would be covered by the program
Over 65’s influenza news
Flu vaccine used in elderly may benefit middle-aged adults with chronic conditions
Expanding the high-dose influenza vaccine recommendation to include middle-aged adults with chronic health conditions may make economic sense and save lives, report scientists at the University of Pittsburgh School of Medicine
Worst flu season in five years on Gold Coast prompts lockdown in nursing homes
Nursing homes are in lockdown as frontline Gold Coast health providers continue to reel from one of the worst flu seasons in decades. In the year to September 17, 448 people were hospitalised suffering from the flu with 4882 “influenza notifications” recorded for the period. An aged care nursing source revealed three homes on the Coast are currently in lockdown due to flu outbreaks. Gold Coast public health unit staff specialist Anu Anuradha said the elderly were the worst affected by what was the toughest flu season in about five years.
Your flu shot might prevent a heart attack or stroke
A study published in the medical journal JAMA found that getting a flu vaccine reduced the risk of heart attack, stroke, heart failure or other major cardiac events — including death — by about a third over the following year
General Influenza News
Influenza Vaccine: Safe Storage Tips
An instructional video posted on the CDC's YouTube page provides pharmacists and other health care professionals with information about safe vaccine storage of the 2017-2018 influenza vaccines. JoEllen Wolicki, a nurse educator with the CDC, notes that that CDC recommends an “in purpose-built unit specifically designed for the storage of biologics, or if necessary, a stand alone household refrigerator” to store flu vaccines
Can Clinicians Influence Influenza Vaccination Rates?
Clinicians have heard plenty of concerns from reluctant patients, ranging from the prudent to the absurd, but patients rarely sit down with data to analyze short- and long-term risks of influenza infection
Influenza vaccine is safe: PHCC expert
With the Qatar influenza vaccination campaign set to kick off on September 24, the Primary Health Care Corporation has assured people that the shot is safe, debunking the myth that the vaccine makes people fall ill
Flu begins making the rounds in Wisconsin; state health officials urge use of flu vaccine
State health officials say the flu season is getting an early start in Wisconsin. Officials with the state say the flu shot is safe and effective for people six months old and older
Flu season near: Doctors recommend not playing ‘viral roulette’
It’s almost flu season and doctors are recommending annual flu shots to reduce the risk of illness, hospitalization, missed work or school or even death. Nasal spray should not be used this season and only injectable vaccines are expected to be effective this year
Swine flu kills 87 in 83 days in Madhya Pradesh
The death toll due to swine flu in Madhya Pradesh stands at 87 in 83 days (July 1 to September 21), even as 129 persons are being treated for the disease in different hospitals, officials said
12 Flu Season Facts You Need to Know
In terms of dominance, no product is more popular among physicians and consumers come flu season than Sanofi's FluZone. FluZone has benefited from being offered in a half-dozen dosing options, including one option featuring a needle that's 90% shorter than a traditional needle
Fighting the flu can be a matter of life and death – so what more can we do?
Australia is coming out of its most deadly influenza season for more than 10 years and experts say increased vaccination alone will not help enough. Australia’s health minister, Greg Hunt, has asked the chief medical officer, Professor Brendan Murphy, to ensure that all aged care workers are properly vaccinated
Maryland Department of Agriculture Update on Swine Influenza
The Maryland State Veterinarian Dr. Michael Radebaugh inspected the pigs under quarantine at the Charles County Fairgrounds as a result of an Influenza A (H3N2 subtype) detection in swine exhibited there
Mass vaccination against swine flu not recommended: Govt panel
A committee set up by the Indian health ministry to review its guidelines on seasonal influenza vaccination (H1N1), in the wake of a spurt in swine flu cases, has said there is “no need” for mass vaccination. The committee has also suggested vaccinating people aged over 65 and children six months to eight years on a case-by-case basis
Overstretched hospitals face winter flu crisis, doctors warn
“Winter last year was relatively mild and without a major outbreak of flu. There are indications that the flu vaccine will not be as successful this year and as such we anticipate that conditions will be even more difficult,” said Dr Taj Hassan, president of the Royal College of Emergency Medicine
Flu warning: Experts warn of UK's worst epidemic for almost 50 years
A spokeswoman for Public Health England said it was: “Continuing to prepare for all scenarios this winter and this includes the implementation of the vaccine programme.” She added: “Our vaccines contain the strains which the World Health Organisation recommends we vaccinate against, based on the best available evidence
Why flu vaccines so often fail
Researchers are questioning what was once received wisdom: that the flu vaccine fails when manufacturers, working months ahead of flu season, incorrectly guess which strains will end up spreading. And they’re learning instead that the vaccine may falter even when the right strains were used to make it, perhaps because of how it is produced or quirks of individual immune systems
How the CDC uses Google, AI, and even Twitter to forecast flu outbreaks
The CDC needs all the information that it can get to prepare for flu season; machine learning is bringing together a staggering amount of data — comprising everything from retail sales of flu medication to Google searches about symptoms — to create the best possible picture of the spread of the virus, as it happens
Burden of disease
‘One confirmed out of 34 suspected H1N1 influenza cases’
A total of 34 suspected cases of H1N1 influenza have been reported so far this year in Punjab with only one case confirmed positive, whereas, last year 443 cases were reported resulting in 31 deaths, said a WHO official. Dr Jamshaid Ahmed, national professional officer, Surveillance and Response, addressing an awareness seminar on pandemic influenza at the University of Health Sciences, said that injectable influenza vaccine was the best immunity for those under threat
More than 650 Victorians hospitalised and scores dead amid worst epidemic in years
More than 650 Victorians have been admitted with the flu to major hospitals — with 9 per cent so severe they were put in intensive care. Experts stressed it showed getting the vaccine was more important than ever
Flu season arrives early in Alaska, especially in the north
The flu season is making an early appearance in Alaska this year, according to state Division of Epidemiology statistics, especially in the northern part of the state. After the typical lull over the summer with fewer than 100 cases per month, the number of laboratory-confirmed flu cases in the state jumped to 159 for the first 19 days of September