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"Seqirus Media Monitoring" 6th Oct 2017

News Highlights
Holly Springs company on the forefront of new flu shot technology Seqirus is leading the world in producing a new type of flu vaccine. "We're charged with a mission for keeping healthy people healthy," said Chad Salisbury, director of supply chain and strategy with Seqirus. Seqirus became the first influenza vaccine company to produce a cell-based influenza vaccine on a commercial scale
DDF 2017: Choosing a CRO, and the implications of new R2 regulations Karen Gardner, senior director of clinical development at Seqirus, talks about the fact that “small biotechs spend a lot less money than the bigger biotechs, but they still get the delivery outcomes.” When choosing a CRO, quality does matter, she adds
Liverpool City Region LEP strengthens board Seven new private sector members have been appointed to the Board of the Liverpool City Region Local Enterprise Partnership (LEP) to help drive the City Region’s economic growth over the next three years. Among the new members is Laura O’Brien, VP & Site Head at Seqirus
Bird flu virus hits Johannesburg The bird flu virus has now hit Johannesburg with 581 birds culled since last month. The City of Johannesburg says most bird carcasses found have tested positive for the H5N8 strain of the virus
Visterra adds $24M to series C to take flu drug to phase 2b Visterra has extended its series C round to fund the advance of its lead candidate into phase 2b. It now has the money to wrap up a phase 2a of influenza A treatment VIS410 in ambulatory patients and start a phase 2b of the same monoclonal antibody in hospitalized patients
'Less precise' study offers another take on FluMist performance A new study provides data showing the live attenuated inactive virus (LAIV) FluMist vaccine was effective in children during the 2015-16 flu season, seemingly contradicting work published 2 months ago that suggested the vaccine offered no protection to recipients in that age-group that year
Woman claims she suffered narcolepsy after receiving swine flu vaccine The Health Products Regulatory Authority has been joined as a defendant in a personal injury case by a woman who claims she suffered narcolepsy after receiving a vaccine for the swine flu virus. Aoife Bennett is among an estimated 70 people who have brought cases against the Minister for Health, the HSE and Glaxosmithkline over being given the Pandemrix vaccine
Shionogi To Present S-033188 Phase 3 CAPSTONE-1 Study Results For Treatment Of Influenza At IDWeek 2017 Shionogi announced it will report results of a S-033188 Phase 3 study in otherwise healthy influenza patients (CAPSTONE-1) at IDWeek 2017. S-033188 is a novel cap-dependent endonuclease inhibitor with potent anti-viral efficacy for the treatment of influenza
Protein-folding mechanism speeds up flu virus evolution Researchers have found that flu viruses’ rapid evolution relies in part on their ability to hijack some of the cellular machinery of the infected host cell. The MIT team showed that a class of cellular proteins known as chaperones, which influence protein folding, can direct the flu virus towards developing certain types of mutations
New tool aims to predict influenza risk Researchers have created a tool to help determine a child’s risk of having influenza and reduce the number being treated unnecessarily. The Suspected Pediatric Influenza Risk-Stratification Algorithm “aids clinicians in determining who to test versus who to treat empirically, saving children from costly viral testing or unnecessary antiviral exposure,” authors wrote
Effective Influenza Vaccine for Elderly Remains Elusive A meta-analysis of studies examining seasonal immunization effectiveness in preventing hospitalization for severe influenza has found that less protection is achieved in the elderly, particularly against influenza A(H3N2) viruses
Seqirus mentions
Holly Springs company on the forefront of new flu shot technology
Seqirus is leading the world in producing a new type of flu vaccine. "We're charged with a mission for keeping healthy people healthy," said Chad Salisbury, director of supply chain and strategy with Seqirus. Seqirus became the first influenza vaccine company to produce a cell-based influenza vaccine on a commercial scale
DDF 2017: Choosing a CRO, and the implications of new R2 regulations
Karen Gardner, senior director of clinical development at Seqirus, talks about the fact that “small biotechs spend a lot less money than the bigger biotechs, but they still get the delivery outcomes.” When choosing a CRO, quality does matter, she adds
Liverpool City Region LEP strengthens board
Seven new private sector members have been appointed to the Board of the Liverpool City Region Local Enterprise Partnership (LEP) to help drive the City Region’s economic growth over the next three years. Among the new members is Laura O’Brien, VP & Site Head at Seqirus
Flu shot season is here
Among the news for the 2017/2018 flu season is that two new quadrivalent flu vaccines have been licensed: one inactivated influenza vaccine (“Afluria Quadrivalent” IIV) and one recombinant influenza vaccine (“Flublok Qudrivalent” RIV)
Pandemic Influenza News
Bird flu virus hits Johannesburg
The bird flu virus has now hit Johannesburg with 581 birds culled since last month. The City of Johannesburg says most bird carcasses found have tested positive for the H5N8 strain of the virus
The fight against the flu
The National Institutes of Health announced that assistant professor of biochemistry Tijana Ivanovic has received a New Innovator Award to conduct research that may improve our chances of forecasting a flu pandemic
H7N9 Flu Changes Worry Experts
Flu experts are watching China uneasily after some unsettling changes in the H7N9 avian influenza A strain during the 2016-17 epidemic in that country. The fifth wave of the virus saw a "huge surge in cases," the CDC's Tim Uyeki, MD, told a symposium at the annual IDWeek meeting
Preparing for Pandemics and Streamlining Vaccine Development
Preparing for a pandemic in the best way is not a single-pronged strategy. Multiple factors are the rule. Given this reality, the threat must be detected early and the response must be swift and effective. Biomedical research is crucial to this process, as is vaccine development
Industry News
Flu vaccine shortage in Queensland pharmacies again
Queensland pharmacies are in the midst of yet another shortage of Tamiflu, as sick patients turn to local compound pharmacists to produce the medication
Woman claims she suffered narcolepsy after receiving swine flu vaccine
The Health Products Regulatory Authority has been joined as a defendant in a personal injury case by a woman who claims she suffered narcolepsy after receiving a vaccine for the swine flu virus. Aoife Bennett is among an estimated 70 people who have brought cases against the Minister for Health, the HSE and Glaxosmithkline over being given the Pandemrix vaccine
Shionogi To Present S-033188 Phase 3 CAPSTONE-1 Study Results For Treatment Of Influenza At IDWeek 2017
Shionogi announced it will report results of a S-033188 Phase 3 study in otherwise healthy influenza patients (CAPSTONE-1) at IDWeek 2017. S-033188 is a novel cap-dependent endonuclease inhibitor with potent anti-viral efficacy for the treatment of influenza
Panther Fusion Flu A/B/RSV Assay Now FDA Cleared on Hologic's New Panther Fusion System
Hologic announced that it has received 510(k) clearance from the United States Food and Drug Administration for its Panther Fusion Flu A/B/RSV assay running on the new Panther Fusion system
Visterra adds $24M to series C to take flu drug to phase 2b
Visterra has extended its series C round to fund the advance of its lead candidate into phase 2b. It now has the money to wrap up a phase 2a of influenza A treatment VIS410 in ambulatory patients and start a phase 2b of the same monoclonal antibody in hospitalized patients
'Less precise' study offers another take on FluMist performance
A new study provides data showing the live attenuated inactive virus (LAIV) FluMist vaccine was effective in children during the 2015-16 flu season, seemingly contradicting work published 2 months ago that suggested the vaccine offered no protection to recipients in that age-group that year
Oxford team to test universal influenza vaccine
Researchers at Oxford University and the biotech firm Vaccitech plan to launch a 2-year clinical trial involving more than 2,000 patients to evaluate a universal influenza vaccine
Academic studies
Protein-folding mechanism speeds up flu virus evolution
Researchers have found that flu viruses’ rapid evolution relies in part on their ability to hijack some of the cellular machinery of the infected host cell. The MIT team showed that a class of cellular proteins known as chaperones, which influence protein folding, can direct the flu virus towards developing certain types of mutations
Pediatric influenza news
Child flu vaccination programme underway in Isles
Parents of 2-5 year olds in the Western Isles are encouraged to join the fight against flu this winter, by ensuring their children get their flu vaccination. GP practices across the NHS Western Isles area are providing the free nasal flu vaccine in a bid to ensure young children are protected
Children’s Health: Older siblings a risk factor for serious flu infections in infants
Having older brothers and sisters puts infants at higher risk for being hospitalised with the flu. Researchers studied 1,115 hospital admissions of children under two born in Scotland from 2007 to 2015. Compared to a firstborn child, a second-born child under six months old was more than two and a half times as likely to be hospitalised
Thousands of school children to be offered flu vaccination
Thousands of children in Rotherham, Bassetlaw, North Lincolnshire and Doncaster will be offered the free flu vaccination. Now parents are being urged to take up the offer of protecting their child in this way
New tool aims to predict influenza risk
Researchers have created a tool to help determine a child’s risk of having influenza and reduce the number being treated unnecessarily. The Suspected Pediatric Influenza Risk-Stratification Algorithm “aids clinicians in determining who to test versus who to treat empirically, saving children from costly viral testing or unnecessary antiviral exposure,” authors wrote
10 Immunizations That Are Recommended for Infants
The influenza vaccine should be administered to all infants starting at 6 months of age. The live attenuated influenza vaccine is not recommended for the 2017 to 2018 flu season due to research demonstrating a lack of efficacy
Over 65’s influenza news
Effective Influenza Vaccine for Elderly Remains Elusive
A meta-analysis of studies examining seasonal immunization effectiveness in preventing hospitalization for severe influenza has found that less protection is achieved in the elderly, particularly against influenza A(H3N2) viruses
General Influenza News
Campaign to create awareness on seasonal influenza vaccination
In Qatar, the Ministry of Public Health in collaboration with Primary Health Care Corporation and Hamad Medical Corporation has launched the national campaign to raise awareness about seasonal influenza vaccination
Health Department urging New Yorkers to get the flu shot
The New York Health Department is urging New Yorkers to get the flu shot this year. Health officials says adults aged 65 years or older, people with certain chronic medical conditions, young children and pregnant women are among those at highest risk for severe flu complications
Flu Epidemic Outbreak in Bulgaria at the End of the Year
The flu strains "Hong Kong" and "Michigan" are expected to hit Bulgaria in a month. Unlike swine flu, which mainly affected people of working age, the new strains are expected to affect mostly the elderly and young children
Regional hospitals earn plaudits for high vaccination rates
Sleepy Eye Medical Center, River’s Edge Hospital and Clinic in St. Peter and Madelia Community Hospital and Clinic all earned blue ribbons in the Minnesota Department of Health’s FluSafe program for having more than 90 percent of its staff vaccinated last year
Vaccination appeal – time to get vaccinated, particularly the elderly who are most at risk
State health authorities across Germany are gearing up through vaccination appeals saying to Germans it is time to get vaccinated, particularly the elderly who are most at risk
Flu is here: get vaccinated
Nearly 12 million French people are entitled to a free flu shot as they belong to at-risk groups. Last year’s vaccine was not very efficient and there’s no telling how well matched this year’s will be
Makati City steps up anti-flu vaccination drive
Makati City has launched a city-wide anti-influenza vaccination program for young students in all public schools and city government employees to curb the number of flu cases. The Makati Health Department started administering the quadrivalent flu vaccine to public school students from kindergarten to grade six
VIDEO: Influenza vaccination among HCWs a ‘patient safety issue’
Infectious Disease News Editorial Board member William Schaffner, MD, medical director of the National Foundation for Infectious Diseases, stresses the importance of influenza vaccination among health care workers and says that providers can increase vaccination rates among patients by being “a flu vaccine insister”
Influenza Vaccine Good Match for Circulating Strains
Influenza activity in the U.S. was low during the summer months, and most of the detected strains match the 2017 to 2018 vaccine, the CDC has reported
CDC encouraging early flu shots to prepare for flu season
Peak flu season is still a couple of months away, but the CDC says to go ahead and get your shot. There is no 100 percent guarantee, but health officials say it is still the best line of defence
Health Officials Say It Could Be A Bad Flu Season
In spite of the yearly recommendations, doctors say fewer than 50 percent of Americans get the annual flu shot, leading to more than nine million flu-related illnesses a year and 12,000 deaths. Steven Alles, the Director of Disease Control at the Philadelphia Department of Public Health got his flu shot and is urging everyone else to follow his lead
Burden of disease
Every third swine flu sample in Rajasthan testing positive, government tells HC
Swine flu positive cases from among the samples sent for test increased more than three times this year in Rajasthan compared to last year, said a state government report
Surge in influenza cases in Western health district with 1300 confirmed cases
More than 1000 extra influenza cases have been confirmed in the Western NSW Local Health district in September compared to September last year. A Western NSW Local Health District spokeswoman said there were 1300 notifications of laboratory-confirmed influenza across the health district last month, compared to 297 notifications in September 2016
Flu season has arrived in N.H.
This year’s flu virus has already infected people in New Hampshire, according to the NH Department of Health Services, and local health practitioners are urging residents to get vaccinated now
Flu cases reported in Michigan, health officials urge flu shot
Flu cases are popping up in Michigan this season, and health officials are urging that people six months and older get vaccinated