|

"Seqirus Media Monitoring" 23rd Oct 2017

News Highlights
Antiviral Therapy for Influenza: To Combine or Not to Combine? In The Lancet Infectious Diseases, researchers described their findings in a multicenter, phase 2 trial comparing outcomes with combination therapy using oseltamivir/amantadine/ribavirin with oseltamivir monotherapy. To date, preclinical data have suggested that combination therapy may be more effective than monotherapy; however, this most recent analysis determined that “although combination treatment showed a significant decrease in viral shedding at day 3”—the primary endpoint of the study—it was not associated with a clinical benefit based on multiple parameters
Influenza Pandemics More Likely to Occur Outside Flu Season Influenza pandemics in the Northern Hemisphere are most likely to emerge outside of the traditional flu season, according to a new study. Future studies may focus on characterizing the cross-strain immunity that hinders pandemic emergence during the traditional flu season, according to the team. Researchers may also examine how pandemic risk patterns occur in both tropical regionals and the Southern Hemisphere
Here's What You Actually Need To Know About The Flu Shot In addition to the standard dose flu shots, there are high-dose shots, recombinant shots, and shots made with an adjuvant. Fluzone is meant for people over 65, Flubok is egg-free, and FLUAD has an immune-boosting supplement
Flu Shots for Seniors There are two different flu shots —Fluzone High-Dose and FLUAD — that are designed specifically for people age 65 and older, offering extra protection beyond what a standard flu shot provides. FLUAD contains an added ingredient called adjuvant MF59 that also helps create a stronger immune response
New H7N9 bird flu strain in China has pandemic potential, U.S.-Japanese lab studies find Lab experiments on a new strain of the H7N9 bird flu suggest the virus can pass easily among animals and can cause lethal disease, raising alarms that it has the potential to create a global human pandemic
Flu Scan for Oct 20, 2017 - IV zanamivir in kids; H5N8 in Italy A phase 2 study of intravenous (IV) zanamivir in children hospitalized with severe influenza found that treatment was safe, reduced viral load, and was associated with clinical improvement, researchers reported in an online edition of Pediatrics
Two New Studies on Influenza Are Nothing to Sneeze At Two new studies on influenza: the first addresses what has happened since withdrawal of LAIV last year and the recommendation that only injectable influenza vaccine (IIV)be used. There were also results of a phase II open-label, multicenter, single-arm study assessing the safety of investigational IV zanamivir for children hospitalized with flu
Older Aged Population Disproportionately Affected by Influenza William Schaffner, MD, medical director for the National Foundation for Infectious Diseases (NFID) and infectious disease physician at Vanderbilt, discusses how the adults aged 65 and older are disproportionately affected by influenza, accounting for the majority of hospitalizations each year
Seqirus mentions
Here's What You Actually Need To Know About The Flu Shot
In addition to the standard dose flu shots, there are high-dose shots, recombinant shots, and shots made with an adjuvant. Fluzone is meant for people over 65, Flubok is egg-free, and FLUAD has an immune-boosting supplement
Flu Shots for Seniors
There are two different flu shots —Fluzone High-Dose and FLUAD — that are designed specifically for people age 65 and older, offering extra protection beyond what a standard flu shot provides. FLUAD contains an added ingredient called adjuvant MF59 that also helps create a stronger immune response
Pandemic Influenza News
Bird flu in Poland? The risk is real and remains very high
Bird flu threats in Poland are a very real threat at this moment due to the migratory season for wild birds. Veterinary services appeal to breeders to strictly comply with biosecurity regulations, otherwise bird flu will spill over into Poland like it did a year ago. Although experts say there is a spark of hope now, the worry is this time Polish poultry farmers relax too much and drop their guard
New H7N9 bird flu strain in China has pandemic potential, U.S.-Japanese lab studies find
Lab experiments on a new strain of the H7N9 bird flu suggest the virus can pass easily among animals and can cause lethal disease, raising alarms that it has the potential to create a global human pandemic
Warning about the spread of a new H5N8 outbreak
Mecklenburg-Vorpommern Agriculture Minister Dr. Till Backhaus is warning all poultry farmers to take the necessary biosafety measures to prevent another bird flu epidemic like the 2016/17 one the industry faced. He urged them to redouble safety efforts in the face of risk from the new spread of H5N8
South Africa: MEC Alan Winde Gives Update On Avian Influenza in Western Cape
There are 56 confirmed cases of avian influenza in the Western Cape. This is up from 50 confirmed cases last week. Alan Winde, Minister of Economic Opportunities, said the number of culled birds stood at 2.7 million, of which 2.6m were layer hens
Avian Influenza detected in Jeolla Province low pathogenic strains
The avian influenza viruses recently detected in central South Korea have been confirmed to be low pathogenic strains, H5N2 and H6N2, the agriculture ministry said. Bird flu viruses were discovered in three samples of wild bird droppings collected from a river in Iksan, about 200 kilometres south of Seoul, on Thursday
Industry News
AstraZeneca EVP: Brexit is hindering our hiring
People are turning down jobs at AstraZeneca because of uncertainty about their right to stay in the United Kingdom after Brexit, according to Mene Pangalos. The AstraZeneca EVP said the ongoing lack of clarity about what will happen to Europeans in the U.K. after March 2019 is leading some scientists to opt for jobs in other countries
There is not enough Tamiflu in the pharmacies around Monterrey
Before the beginning of the flu season, Monterrey in Mexico is experiencing a shortage of Tamiflu, even though the flu vaccine campaign has begun
Flu Scan for Oct 20, 2017 - IV zanamivir in kids; H5N8 in Italy
A phase 2 study of intravenous (IV) zanamivir in children hospitalized with severe influenza found that treatment was safe, reduced viral load, and was associated with clinical improvement, researchers reported in an online edition of Pediatrics
Academic studies
Antiviral Therapy for Influenza: To Combine or Not to Combine?
In The Lancet Infectious Diseases, researchers described their findings in a multicenter, phase 2 trial comparing outcomes with combination therapy using oseltamivir/amantadine/ribavirin with oseltamivir monotherapy. To date, preclinical data have suggested that combination therapy may be more effective than monotherapy; however, this most recent analysis determined that “although combination treatment showed a significant decrease in viral shedding at day 3”—the primary endpoint of the study—it was not associated with a clinical benefit based on multiple parameters
Influenza Pandemics More Likely to Occur Outside Flu Season
Influenza pandemics in the Northern Hemisphere are most likely to emerge outside of the traditional flu season, according to a new study. Future studies may focus on characterizing the cross-strain immunity that hinders pandemic emergence during the traditional flu season, according to the team. Researchers may also examine how pandemic risk patterns occur in both tropical regionals and the Southern Hemisphere
Research Roundup: Flu pandemics may be more likely in spring and early summer
U.S. researchers developed a computational model that mimics viral spread during flu season, incorporating real-world data on flu transmission from the 2008-09 flu season. They found that cross-virus immunity delayed wintertime spread of new strains and led to spring and summer pandemics, which the authors suggest could help public health agencies detect and respond to new viral threats
Intravenous Zanamivir in Hospitalized Patients With Influenza
Results from a study investigating intravenous (IV) zanamivir for the treatment of hospitalized infants and children with influenza showed that the safety profile of IV zanamivir was favorable, with no drug-related STEAEs reported. The majority of children experienced virologic response and clinical improvement during the treatment course. Systemic zanamivir exposures in children were consistent with adults
Two New Studies on Influenza Are Nothing to Sneeze At
Two new studies on influenza: the first addresses what has happened since withdrawal of LAIV last year and the recommendation that only injectable influenza vaccine (IIV)be used. There were also results of a phase II open-label, multicenter, single-arm study assessing the safety of investigational IV zanamivir for children hospitalized with flu
The Flu Vaccine has some healthy competition
A EurekaFacts study showed that those who think a strong immune system can prevent the flu are less likely to get a flu shot. "Understanding Flu Vaccination in a Competitive Context" instead found they are engaging in alternative healthy behaviours such as taking vitamins, good nutrition, eating specific "superfoods," and dressing warmly
Pediatric influenza news
Free nasal spray available for children aged two to eight
Parents in the Tivyside area of Wales are being urged to get children aged two to eight protected against flu with a simple, free NHS nasal spray vaccine this winter. The vaccine is available to children who were aged between two and eight on August 31
Over 65’s influenza news
Older Aged Population Disproportionately Affected by Influenza
William Schaffner, MD, medical director for the National Foundation for Infectious Diseases (NFID) and infectious disease physician at Vanderbilt, discusses how the adults aged 65 and older are disproportionately affected by influenza, accounting for the majority of hospitalizations each year
General Influenza News
NHS trusts pressuring staff to help meet vaccination targets
Front-line NHS staff claim they are getting ever-increasing pressure to receive the seasonal influenza vaccine as cash-strapped NHS trusts strive to hit the ‘Flu Fighter’ CQUIN, which provides significant financial incentives for trusts who vaccinate a proportion of their staff
The flu vaccination protects you relatively well
Local health expert Dr Andreas Lang recoemmended that pregnant women, the elderly and everyon in the most at risk groups get vaccinated against the flu this winter
British flu deaths "may rise in worst epidemic in 50 years" after Australian strain outbreak
A flu strain that has laid low at least 98,000 Australians is on its way to the UK and could cause its worst such epidemic for 50 years. Dr Ian Gray, medical head of Sanofi Pasteur UK & Ireland, said: “The medical community has been concerned at the low number of eligible people in at-risk groups taking up the NHS flu vaccination”
Cheap yoghurt drinks can make the flu jab work better: Study reveals consuming probiotics after vaccination boosts effectiveness
Taking probiotic supplements after having your flu jab could make it work better, research suggests. Scientists claim the yoghurt drinks offer a cheap boost; University of Melbourne researchers reviewed 26 trials of people who consumed probiotics after getting various jabs to make the finding
Merkel backs the call for vaccinations against diseases
Although speaking mainly about polio the Federal Chancellor Angela Merkel came out strongly of vaccinations to prevent disease and save lives, now, during the flu season too
Aargauer pharmacists and doctors are working side-by-side on the flu vaccination campaign
Relations between pharmacists and doctors have not always been cordial. Now, however, the presidents of the two professional associations have issued a joint message. It says that Aargauer doctors and pharmacists will carry out flu vaccination day on 3 November for the first time together. Three years ago the doctors complained that patient privacy was not protected in the pharmacy and that they were not prepared for emergencies if they were to occur
Diabetes UK urges diabetes sufferers to get essential flu jab this winter
Diabetes UK is calling for everyone with diabetes, including those who are pregnant, to have a flu vaccination this winter, as illnesses like the flu can be more severe for people with diabetes. Current figures show almost a quarter of people with diabetes did not have a flu jab in England last winter, despite it being free to everyone with the condition
8,000 flu vaccine doses to fight the virus arrive in La Laguna
In La Laguna, Mexico, 8,000 flu vaccines are available for at-risk groups, as well as the general public; more vaccines will be brought in should these all get used up
Venetian doctors raise awareness of flu vaccination
In Venice, doctors are raising awareness of the flu and the benefits of getting the flu vaccine for the coming season
Several pharmacies in the canton of Valais will be offering vaccination against seasonal influenza this autumn
In the Swiss canton of Valais, several pharmacies will be administering the flu vaccine from this autumn, without the need for a prescription, to people without any health problems between the ages of 16 and 65
Ostholstein: There was a strong increase in the number of influenza cases over the last year
From October 2016 to the end of September 2017 a total of 2,309 Schleswig-Holsteiners fell ill with the flu, one year earlier for the same period the number was 1,583 cases. This was an increase of almost 50 percent
Surprisingly simple way boost your flu shot"s effectiveness
A recent study recruited 138 adults aged 65 to 85, collecting data for two weeks before a flu shot about food and drink consumption, physical activity, stress levels, sleep, and having a positive or negative outlook. Researchers found that only one of them was predictive of higher flu antibodies four weeks after the flu shot: a positive mood
Public health officials work toward "achieving herd immunity against influenza"
The Bartow County Health Department and some other flu-vaccine providers in the community are offering the quadrivalent flu vaccine that provides broader protection against circulating flu viruses and is approved for people 6 months and older and the Fluzone high-dose vaccine for adults 65 and older who are at greater risk of severe illness from influenza
Hundreds of local veterans may have received ineffective flu shots
More than 1,500 veterans should begin learning next week whether they received a flu vaccine that may not work because it was stored in a broken refrigerator, a Veterans Affairs San Diego Healthcare System spokesman said
Flu vaccines MUST be used to avoid deadly complications, urges Paula Radcliffe
Heart disease, asthma and diabetes sufferers must make us of flu vaccines, urged three-time London marathon winner Paula Radcliffe. Doctors have been worrying about the small numbers of at-risk patients being vaccinated, according to vaccine maker Sanofi Pasteur
Singapore: MOH says adults can use Medisave to pay for recommended vaccines
Singapore's Ministry of Health announced on Saturday that adults can use Medisave to pay for recommended vaccinations, which include influenza , as part of a new immunisation schedule from November 1, 2017
Screening of anti-vaccination film 'could cost kids' lives'
Doctors are warning an anti-vaccination documentary to be screened across regional Queensland could ultimately cost children's lives. The film Vaxxed, which makes false and disproved links between vaccination and autism, is set to be shown in 11 Queensland towns and cities between October 21 and November 5
New flu detection technology set to boost CQ's flu response
A significant investment into flu detection technology has CQ better poised when the next flu season rolls around. The new technology which is capable of diagnosing influenza more quickly will be introduced at Rockhampton Hospital next year
1 in 4 French people still do not trust vaccinations
One in four French people still do not trust vaccinations, despite the forthcoming bill to make them compulsory, and their proven effectiveness, says a new study from Public Health France. The least popular vaccination was found to be the ‘flu jab (15.4% were reluctant to support this), compared to the Hepatitis B jab (13% against it) and HPV vaccination (5.8% against)
"More people than ever before" offered flu jab, says health chief
The elderly, pregnant women, children and those with long-term conditions in Wirral are being urged to get their free flu vaccination ahead of winter. A spokeswoman for NHS England Cheshire & Merseyside said the jab is being offered free to more people than ever, including care home workers and more children
Burden of disease
District's swine flu death rate 4 times more than national average
The death rate due to swine flu in Nagpur division in India is four times more than the average of the entire country, the latest data by the state government has revealed. Altogether 37,107 cases of swine flu have been reported in the country so far this year, of which 2,025 people have died. Accordingly, the death rate due to the deadly virus is 5.45%
Flu hospitalizations already reported in El Paso County
Though flu season started October 1st, state-wide across Colorado there are already 27 hospitalizations according to the Colorado Department of Health. Experts said it's still too early to know just how serious this flu season will be and health officials urge everyone to get a flu shot this season